Thymic Mucosa-Associated Lymphoid Tissue Lymphoma

Preferred Label : Thymic Mucosa-Associated Lymphoid Tissue Lymphoma;

NCIt synonyms : Thymic Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Mediastinal Mucosa-Associated Lymphoid Tissue Lymphoma; Primary Thymic Extranodal Marginal Zone Lymphoma; MALT Lymphoma of the Mediastinum;

NCIt definition : A low-grade extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that affects the thymus. It is characterized by the presence of centrocyte-like or monocytoid lymphocytes that surround reactive lymphoid follicles. There is infiltration of the thymic epithelium by lymphocytes and formation of lymphoepithelial lesions. It is associated with the presence of autoimmune disease, most frequently Sjogren syndrome. Patients are usually asymptomatic and the tumor is detected incidentally as a mediastinal mass on chest x-ray. A minority of patients present with dyspnea, hemoptysis, and chest pain. The prognosis is excellent.;

Neoplastic status : Malignant;

Details

Origin ID

C45380;

UMLS CUI

C1710402;

Disease excludes abnormal cell
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
- Reed-Sternberg Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Plasma Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Lymphoepithelial Lesion [NCIt concept]
Excludes anatomical site(s)
- Lymph Node [NCIt concept]
- Neck [NCIt concept]
- Skin [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
- Mediastinum [NCIt concept]
- Respiratory System [NCIt concept]
- Thoracic Cavity [NCIt concept]
- Thymus Gland [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Aggressive Clinical Course [NCIt concept]
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Centrocyte-Like Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
disease_has_finding
- Extranodal Disease [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Marginal Zone B-Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
- Postgerminal Center Marginal Zone B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
- Marginal Zone [NCIt concept]
- Mucosa-Associated Lymphoid Tissue [NCIt concept]
- Thymic Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
- Mediastinum [NCIt concept]
- Thymus Gland [NCIt concept]
disease_may_have_abnormal_cell
- Neoplastic Monocytoid B-Lymphocyte [NCIt concept]
- Neoplastic Plasma Cell [NCIt concept]
disease_may_have_associated_disease
- Sjogren Syndrome [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Trisomy 18 [NCIt concept]
- Trisomy 3 [NCIt concept]

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