Diffuse Large B-Cell Lymphoma Unclassifiable

Preferred Label : Diffuse Large B-Cell Lymphoma Unclassifiable;

NCIt synonyms : Diffuse Large B-Cell Lymphoma Indeterminate; Type 3 DLBCL; Type 3 Diffuse Large B-Cell Lymphoma; DLBCL Unclassifiable;

NCIt definition : A biologic subset of diffuse large B-cell lymphomas (DLBCL) that do not overexpress the genes whose overexpression characterizes the germinal center B-cell-like and activated B-cell-like DLBCL. Morphologically, these lymphomas are either immunoblastic or centroblastic. Patients with this type of diffuse large B-cell lymphoma are reported to have a less favorable outcome, similar to those with an activated B-cell-like gene expression profile.;

Neoplastic status : Malignant;

Details

Origin ID

C45231;

UMLS CUI

C1710498;

Disease excludes abnormal cell
- Lymphocyte Predominant Cell [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
- Plasmablastic Immunoblast [NCIt concept]
- Reed-Sternberg Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Plasma Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
- Thymic B-Lymphocyte [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Lymphadenopathy [NCIt concept]
Excludes anatomical site(s)
- Thymus Gland [NCIt concept]
- Vascular System [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Diffuse large B-cell lymphoma, unclassifiable, NOS [MedDRA LLT]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Histiocytosis [NCIt concept]
disease_excludes_molecular_abnormality
- ALK Kinase Overexpression [NCIt concept]
- BCL2 Gene Translocation [NCIt concept]
- Cyclin D2 Messenger RNA Overexpression [NCIt concept]
- IRF4/MUM1 Messenger RNA Overexpression [NCIt concept]
- REL Gene Amplification [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Large B-Lymphocyte [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
disease_has_finding
- Diffuse Pattern [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Not Otherwise Specified Lesion [NCIt concept]
- Unclassifiable Lesion [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_may_have_molecular_abnormality
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement [NCIt concept]

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