Distamycin Antineoplastic Antibiotic

Preferred Label : Distamycin Antineoplastic Antibiotic;

NCIt synonyms : Distamycins; Distamycin Antibiotic;

NCIt definition : An antineoplastic antibiotic isolated from the bacterium Streptomyces distallicus. Distamycin antibiotics bind to the minor groove of DNA, preferentially to adenine-thymine (A-T) rich sequences, thereby inhibiting DNA replication and RNA transcription. In addition to their antitumor effects, these agents possess antiviral and antiprotozoal activities.;

Details

Origin ID

C446;

UMLS CUI

C0012750;

Automatic exact mappings (from CISMeF team)
- stallimycin [MeSH Supplementary Concept]
- stallimycin [MeSH concept]
Currated CISMeF NLP mapping
- distamycins [MeSH Descriptor]
- distamycins [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Antibiotic [UMLS semantic type]
UMLS correspondences (same concept)
- distamycins [MeSH concept]
- distamycins [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

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