Preferred Label : Methoxsalen with Ultraviolet A Therapy;
NCIt synonyms : Ultraviolet Light Therapy Using Methoxsalen; 8-Methoxypsoralen Plus Ultraviolet Radiation; PUVA;
NCIt related terms : psoralen and ultraviolet A therapy; PUVA therapy;
NCIt definition : Strong evidences have indicated causal association between 8-methoxypsoralen with
UVA (PUVA) treatment and non-melanocytic skin patients with psoriasis. 8-Methoxypsoralen
alone did not alter the incidence of new skin cancer development in a 2-year study.
In a large number of studies, 8-Methoxypsoralen in combination with ultraviolet A
radiation induced chromosomal aberrations, sister chromatid exchanges, mutation, DNA
damage and DNA cross-links in human cells in vitro. This treatment is classified as
carcinogenic to Human by IARC. (NCI05);
Alternative definition : NCI-GLOSS: A type of photodynamic therapy used to treat skin conditions such as psoriasis,
vitiligo, and skin nodules of cutaneous T-cell lymphoma. The patient receives psoralen
(a drug that becomes active when it is exposed to light) by mouth or applied to the
skin, followed by ultraviolet A radiation. Psoralen and ultraviolet A therapy may
increase the risk of getting skin cancer.;
Codes from synonyms : CDR0000439423; CDR0000439424;
Origin ID : C44398;
UMLS CUI : C1704892;
Currated CISMeF NLP mapping
- PUVA [MedDRA Preferred Term]
- Semantic type(s)
