Rectosigmoid Signet Ring Cell Carcinoma

Preferred Label : Rectosigmoid Signet Ring Cell Carcinoma;

NCIt synonyms : Rectosigmoid Signet-Ring Cell Carcinoma;

NCIt definition : An infiltrating adenocarcinoma arising from the rectosigmoid area. It is characterized by the presence of malignant glandular cells with prominent intracytoplasmic mucin. These cells constitute more than 50% of the malignant cellular population.;

Neoplastic status : Malignant;

Details

Origin ID

C43593;

UMLS CUI

C1709869;

Disease excludes abnormal cell
- Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
Disease may have findings
- Abdominal Pain [NCIt concept]
- Constipation [NCIt concept]
- Fever [NCIt concept]
- Lower Gastrointestinal Hemorrhage [NCIt concept]
- Tenesmus [NCIt concept]
- Weight Loss [NCIt concept]
Has associated anatomic sites
- Colorectal Region [NCIt concept]
- Digestive System [NCIt concept]
- Intestine [NCIt concept]
- Rectosigmoid Region [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Intermediate Grade Neuroendocrine Lesion [NCIt concept]
- Intestinal Metaplasia [NCIt concept]
- Low Grade Neuroendocrine Lesion [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
- Well Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_abnormal_cell
- Adenocarcinoma Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
- Signet Ring Adenocarcinoma Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Poorly Cohesive Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Glandular Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Glandular Epithelium [NCIt concept]
- Large Intestinal Mucosa [NCIt concept]
disease_has_primary_anatomic_site
- Colorectal Region [NCIt concept]
- Digestive System [NCIt concept]
- Rectosigmoid Region [NCIt concept]
disease_mapped_to_gene
- APC Gene [NCIt concept]
- BRAF Gene [NCIt concept]
- KRAS Gene [NCIt concept]
- TP53 Gene [NCIt concept]
disease_may_have_molecular_abnormality
- BRAF Gene Mutation [NCIt concept]
- High-Frequency Microsatellite Instability [NCIt concept]
- Inactivating APC Gene Mutation [NCIt concept]
- KRAS Gene Amplification [NCIt concept]
- MYC Gene Mutation [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]

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