Mantle Cell Lymphoma

Preferred Label : Mantle Cell Lymphoma;

NCIt synonyms : MCL; Classical Mantle Cell Lymphoma;

NCIt related terms : Mantle zone lymphoma; Mantle cell lymphoma, unspecified site;

NCIt definition : A non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA.;

Alternative definition : NCI-GLOSS: An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that usually occurs in middle-aged or older adults. It is marked by small- to medium-size cancer cells that may be in the lymph nodes, spleen, bone marrow, blood, and gastrointestinal system.;

Neoplastic status : Malignant;

ICD-O code : 9673/3;

Codes from synonyms : 10026799; CDR0000445048; C83.10;

Details

Origin ID

C4337;

UMLS CUI

C4721414;

Currated CISMeF NLP mapping
- Mantle cell lymphoma [PASCAL descriptor]
- Mantle cell lymphoma [ICD-O code]
- Mantle cell lymphoma [ICD-11 Subcategory]
- Mantle cell lymphoma [MedDRA Preferred Term]
- Mantle cell lymphoma [ORDO Disease]
- Mantle cell lymphoma (disorder) [SNOMED CT concept]
- Mantle cell lymphoma (morphologic abnormality) [SNOMED CT concept]
- Mantle cell lymphoma NOS [MedDRA LLT]
- Mantle cell lymphomas [MedDRA High Level Term]
- Mantle zone lymphoma [MedDRA LLT]
- lymphoma, Mantle-Cell [MeSH concept]
- lymphoma, mantle-cell [MeSH Descriptor]
- mantle cell lymphoma [DO Concept]
- mantle cell lymphoma [Disease (Nov.)]
Disease excludes abnormal cell
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
- Reed-Sternberg Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Plasma Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Lymphadenopathy [NCIt concept]
False automatic mappings
- Hereditary leiomyomatosis and renal cell cancer [OMIM Phenotype]
- Per microliter (qualifier value) [SNOMED CT concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Manual BTNT mappings - CISMeF
- classic mantle cell lymphoma [Disease (Nov.)]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Mantle cell lymphoma [MedDRA Preferred Term]
- Mantle cell lymphoma [ICD-O code]
- Mantle cell lymphoma [ICD-10 Sub-category]
- Mantle cell lymphoma [PASCAL descriptor]
- Mantle cell lymphoma [ICD-9 code]
- Mantle cell lymphoma (disorder) [SNOMED CT concept]
- Mantle cell lymphoma (morphologic abnormality) [SNOMED CT concept]
- Mantle cell lymphoma NOS [MedDRA LLT]
- Mantle cell lymphomas [MedDRA High Level Term]
- Mantle zone lymphoma [MedDRA LLT]
- lymphoma, Mantle-Cell [MeSH concept]
- lymphoma, mantle-cell [MeSH Descriptor]
- malignant lymphoma, lymphocytic, intermediate differentiation, diffuse [SNOMED Notion]
- mantle cell lymphoma [DO Concept]
- mantle cell lymphoma [Disease (Nov.)]
concept_is_in_subset
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCI CTEP SDC Non-Hodgkin Lymphoma Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
- mCode Cancer Disorder Value Set [NCIt concept]
- mCode Elixhauser Lymphoma Value Set [NCIt concept]
- mCode Primary Cancer Disorder Value Set [NCIt concept]
- mCode Primary Malignant Neoplasm Disorder Value Set [NCIt concept]
- mCode Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic Small to Medium-Sized B-Lymphocyte Resembling a Centrocyte [NCIt concept]
disease_has_accepted_treatment_with_regimen
- EPOCH Regimen [NCIt concept]
- EPOCH-R Regimen [NCIt concept]
- R-CHOP Regimen [NCIt concept]
- R-CHOP-Methotrexate Regimen [NCIt concept]
- R-maxi-CHOP Regimen [NCIt concept]
disease_has_finding
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
- Peripheral B-Lymphocyte of Inner Mantle Zone [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
- Mantle Zone [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome 17p [NCIt concept]
- Trisomy 12 [NCIt concept]
- del(13q14) [NCIt concept]
may_be_associated_disease_of_disease
- Multifocal Lymphomatous Polyposis [NCIt concept]

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