Myeloid Leukemia Associated with Down Syndrome

Preferred Label : Myeloid Leukemia Associated with Down Syndrome;

NCIt synonyms : Acute Myeloid Leukemia Transient Myeloproliferative Disorder in Down Syndrome;

NCIt related terms : AML Occurring in Children with Down Syndrome; MLDS; Acute Myeloid Leukemia with GATA1 Mutations; Acute Myeloid Leukemia Occurring in Children with Down syndrome;

NCIt definition : Acute myeloid leukemia or myelodysplastic syndrome occurring in children with Down syndrome. The acute myeloid leukemia is usually an acute megakaryoblastic leukemia, and is associated with GATA1 gene mutation.;

Alternative definition : NICHD: Acute myeloid leukemia occurring in children with Down syndrome. During the first 3 years of life, it is usually the megakaryoblastic subtype, and is associated with GATA1 gene mutation. After age 4 this is no longer the case.;

Neoplastic status : Malignant;

ICD-O code : 9898/3;

Details

Origin ID

C43223;

UMLS CUI

C2825149;

Automatic exact mappings (from CISMeF team)
- Myeloid leukaemia associated with Down Syndrome [ICD-11 Extension code]
- Myeloid leukaemia associated with Down syndrome [ICD-11 Sub-sub category]
- Myeloid leukemia associated with Down Syndrome (morphologic abnormality) [SNOMED CT concept]
- myeloid leukemia associated with Down Syndrome [DO Concept]
Currated CISMeF NLP mapping
- Myeloid leukemia associated with Down Syndrome (morphologic abnormality) [Inactive SNOMED CT concept]
Disease may have findings
- Hypercellular Bone Marrow [NCIt concept]
- Leukocytosis [NCIt concept]
- Thrombocytopenia [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Trisomy 21 [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Myeloid leukemia associated with Down Syndrome (morphologic abnormality) [SNOMED CT concept]
- Myeloid leukemia associated with Down syndrome (disorder) [SNOMED CT concept]
concept_is_in_subset
- AML Authorized Value Terminology [NCIt concept]
- AML Disease Characteristics Table [NCIt concept]
- AML Variable Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Thrombocytopenia [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Blast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_associated_disease
- Down Syndrome [NCIt concept]
disease_has_associated_gene
- GATA1 Gene [NCIt concept]
- GATA1 wt Allele [NCIt concept]
disease_has_finding
- Childhood Lesion [NCIt concept]
- Hereditary Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Preexisting Condition [NCIt concept]
disease_has_molecular_abnormality
- Germline Variation [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- GATA1 Gene [NCIt concept]
disease_may_have_abnormal_cell
- Micromegakaryocyte [NCIt concept]
- Neoplastic Megakaryoblast [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Trisomy 8 [NCIt concept]
disease_may_have_molecular_abnormality
- GATA1 Gene Mutation [NCIt concept]

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