NCIt definition : A rare variant of diffuse astrocytoma. It is characterized by the presence of a conspicuous,
though variable, fraction of gemistocytic neoplastic astrocytes. Gemistocytes are
round to oval astrocytes with abundant, glassy, non-fibrillary cytoplasm which appears
to displace the dark, angulated nucleus to the periphery of the cell. To make the
diagnosis of gemistocytic astrocytoma, gemistocytes should amount to more than approximately
20% of all tumor cells. (Adapted from WHO);