Ditiocarb - CISMeF

Preferred Label : Ditiocarb;

NCIt synonyms : Diethyldithiocarbaminic Acid; Diethyldithiocarbamic Acid; DTC; Diethyldithione; DIECA; DDTC; Diethyldione; Diethyldithiocarbamate;

NCIt related terms : Diethylcarbamodithioic Acid;

NCIt definition : A sulfhydryl-containing carbamate that is the primary in vivo metabolite of disulfiram. Diethyldithiocarbamate chelates zinc, thereby inhibiting metalloproteinases, thereby preventing the degradation of the extracellular matrix and inhibiting an initial step in cancer metastasis and angiogenesis. A known inhibitor of superoxide dismutase, this agent can either potentiate or protect against cell oxidative damage caused by ionizing radiation, depending on the time of administration. (NCI04);

UNII : 99Z2744345;

InChIKey : LMBWSYZSUOEYSN-UHFFFAOYSA-N;

CAS number : 147-84-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 147-84-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C5H11NS2;

Codes from synonyms : 01360;

Details

Origin ID

C432;

UMLS CUI

C0012194;

Automatic exact mappings (from CISMeF team)
- Direct-to-consumer advertising [Terme SASMAG]
- diethyldithiocarbamic acid [Substance BNPC]
- ditiocarb [MeSH concept]
- ditiocarb [MeSH Descriptor]
Currated CISMeF NLP mapping
- diethyldithiocarbamate [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- diethyldithiocarbamic acid [Substance BNPC]
- ditiocarb [MeSH Descriptor]
- ditiocarb [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/Diethyldithiocarbamate [NCIt concept]
- Cisplatin/Cyclophosphamide/Diethyldithiocarbamate [NCIt concept]

Keyword's position in hierarchy(ies) :

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