Preferred Label : Preservative Excipient;
NCIt synonyms : Drug Preservative;
NCIt related terms : Preservative;
NCIt definition : Chemicals that are added to drug products to prolong shelf life and maintain sterility.
Protection of formulations, especially aqueous solutions, against microbial growth
requires use of either antibacterial or antifungal preservatives. Generally, such
agents are active against either bacteria or fungi but a few are active against both.
The antimicrobials include but not limited to chlorobutanol, benzyl alcohol, sodium
benzoate, sorbic acid, and phenol. The antioxidizing agents include butylated hydroxytoluene,
hydroxyanisole, propyl gallate, and sulfites. The necessary addition of preservatives
for both safety and economy sometimes has been associated with significant adverse
effects in certain patient populations.;
Alternative definition : PQCMC: An agent added to extend the shelf-life of a formulation (e.g. antibacterial
agent; antifungal agent preservative; fungicides; antimicrobial preservative; antiviral
agent preservative; viricides; sterilizing agent; glazing agent).;
Origin ID : C42659;
UMLS CUI : C0033086;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
