Preferred Label : Disintegrant Excipient;
NCIt synonyms : Disintegrant;
NCIt definition : Disintegrant excipient is a therapeutically inactive ingredient of a solid pharmaceutical
dosage form that helps the form to dissolve within the gastrointestinal tract to ensure
full release of the pharmaceutically active material. Disintegration rate of the tablet
may be the rate limiting step for the absorption of the drug. Currently, disintegrants
have been developed to the point that disintegration is not usually the rate limiting
step. The US Pharmacopeia sets a time limit for disintegration. Microcrystalline cellulose
and starch are examples of disintegrants.;
Alternative definition : PQCMC: An agent used to facilitate breakup or disintegration after administration.
Functional components that are added to formulations to promote rapid disintegration
into smaller units and to allow a drug substance to dissolve more rapidly. (Pharmaceutical
Excipients: A review Shilpa P Chaudhari and Pradeep S Patil Marathwada Mitra Mandal's
College of Pharmacy, Thergaon, Pune, Maharashtra, India. USP 1059 );
Origin ID : C42648;
UMLS CUI : C1707792;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
