NCIt definition : An inactive ingredient of the solid pharmaceutical dosage form added to cement the
active and inert components of tablets together to maintain cohesive and discrete
portions. These are especially important in the production of time-release products.
Binders provide the matrix from which the drug is gradually secreted. Binding agents
which have adhesive properties are important excipients, especially for lozenges and
tablets. The choice of the particular binder or thickening agent is dependent upon
the desired properties of adhesive strength and thickness. Thus, one would be a better
agent for a lozenge when slow dissolution in the mouth is desirable whereas another
would provide more rapid disintegration for other purposes. The commonly used binder
excipients in U.S.-manufactured drug products are microcrystalline cellulose and starch.;
Alternative definition : NCI-GLOSS: A substance that makes a loose mixture stick together. For example, binding
agents can be used to make solid pills from loose powders.; PQCMC: Impart cohesive qualities to powdered material (e.g. binding agent or wet binder).
(Pharmaceutical Excipients: A review Shilpa P Chaudhari and Pradeep S Patil Marathwada
Mitra Mandal's College of Pharmacy, Thergaon, Pune, Maharashtra, India. USP 1059
);
Automatic exact mappings (from CISMeF team)