NCIt definition : A Leydig cell tumor characterized by large tumor size, the presence of cytologic atypia,
increased mitotic activity, necrosis, and vascular invasion. Approximately 10% of
the testicular Leydig cell tumors show malignant characteristics and metastasize.
Leydig cell tumors of the ovary follow a benign clinical course.;
Alternative definition : CDISC: A malignant neoplasm of the testis originating from interstitial (Leydig) cells.;