Demecolcine - CISMeF

Preferred Label : Demecolcine;

NCIt synonyms : Santavy's Substance F; (-)-Colchamine; Methylcolchicine; N-Methyl-N-desacetylcolchicine;

NCIt definition : A colchicine analog with potential antimitotic and antineoplastic activities. Demecolcine acid binds to the colchicine-binding site of tubulin, inhibiting its polymerization into microtubules, causing cell cycle arrest at metaphase and preventing cell division.;

UNII : Z01IVE25KI;

InChIKey : NNJPGOLRFBJNIW-HNNXBMFYSA-N;

CAS number : 477-30-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 477-30-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : X 153;

Chemical formula : C21H25NO5;

NSC code : 403147; 3096;

ChEBI ID : CHEBI:4393;

Codes from synonyms : NSC0403147;

Details

Origin ID

C419;

UMLS CUI

C0011259;

Automatic exact mappings (from CISMeF team)
- Demecolcine [ICHI extension code]
Currated CISMeF NLP mapping
- Demecolcine [ICD-11 Extension code]
- demecolcine [Substance BNPC]
- demecolcine [MeSH Descriptor]
- demecolcine [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Demecolcine [ICD-11 Extension code]
- demecolcine [ATC Code]
- demecolcine [Substance BNPC]
- demecolcine [MeSH concept]
- demecolcine [MeSH Descriptor]
Validated automatic mappings to BTNT
- demecolcine [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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