Farnesylation Process

Preferred Label : Farnesylation Process;

NCIt synonyms : Farnesylation; Farnysylation;

NCIt definition : A likely membrane attachment device, farnesylation involves enzymatic covalent addition of farnesyl group(s) (three isoprene units) to polypeptide chains that contain the carboxyl terminal motif CAAX. The addition involves cleavage and addition to the free thiol group of cysteine moiety, and methylation of the free carboxylate group on the protein's carboxyl terminus.;

Details

Origin ID

C41582;

UMLS CUI

C0162763;

Automatic exact mappings (from CISMeF team)
- prenylation [MeSH Descriptor]
Currated CISMeF NLP mapping
- farnesylation [MeSH concept]
Semantic type(s)
- Phenomenon or Process [UMLS semantic type]
UMLS correspondences (same concept)
- farnesylation [MeSH concept]
biological_process_involves_gene_product
- Protein Farnesyltransferase Subunit Beta [NCIt concept]
biological_process_is_part_of_process
- Membrane Protein Traffic [NCIt concept]
- Post-Translational Regulation [NCIt concept]
process_involves_gene
- FNTB Gene [NCIt concept]
- FNTB wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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