Preferred Label : Complement Degradation Process;
NCIt synonyms : Complement Degradation;
NCIt definition : Complement Degradation consists of conjugation, transport, oxidation, and/or proteolysis
of complement system proteins; sequentially interacting serum proteins (some serine
proteases), their receptors, and related regulatory proteins. Activated by cell-surface
bound antibody, immune complexes, or a microbial membrane carbohydrate, complex complement
cascades (classical or properdin pathway) generate Membrane Attack Complex, which
creates target cell wall pores and lysis. The complement system also plays a role
in antibody-dependent cytolysis, anaphylaxis, phagocytosis, opsonization, chemotaxis,
and hemolysis.;
Origin ID : C40677;
UMLS CUI : C1516744;
Semantic type(s)
- biological_process_is_part_of_process
