Preferred Label : Plasminogen Activator Interaction;
NCIt definition : Plasminogen Activator Interaction involves temporary non-covalent binding through
intermolecular physical forces of attraction with heterogeneous group of widely expressed
lysosomal and secreted serine proteases having fibrin-binding activity that convert
plasminogen to fibrinolytic plasmin. Inhibited by PAI-1, encoded by the PLAT Gene
(Peptidase S1 Family), and cleaved by plasmin, tissue kallikrein, or factor XA to
disulfide-linked A/B chains, tissue-type plasminogen activator plays a role in cell
migration and tissue remodeling.;
Origin ID : C40529;
UMLS CUI : C1514153;
Semantic type(s)
- biological_process_is_part_of_process
