Cycloleucine - CISMeF

Preferred Label : Cycloleucine;

NCIt synonyms : 1-Aminocyclopentane; 1-aminocyclopentanecarboxylic acid; ACPC; ACP;

NCIt related terms : CB 1639;

NCIt definition : A non-metabolizable synthetic amino acid, formed through the cyclization of the amino acid leucine, with immunosuppressive, antineoplastic, and cytostatic activities. Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production; RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted. This agent is also a competitive inhibitor at the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor.;

UNII : 0TQU7668EI;

InChIKey : NILQLFBWTXNUOE-UHFFFAOYSA-N;

CAS number : 52-52-8;

Molecule name : CB-1639;

Chemical formula : C6H11NO2;

NSC code : 1026;

Codes from synonyms : NSC0001026;

Details

Origin ID

C404;

UMLS CUI

C0010575;

Currated CISMeF NLP mapping
- 1-aminocyclopentane-1-carboxylic acid [Substance BNPC]
- Cycloleucin [ICD-11 Extension code]
- cycloleucine [MeSH Descriptor]
- cycloleucine [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 1-aminocyclopentane-1-carboxylic acid [Substance BNPC]
- Cycloleucin [ICD-11 Extension code]
- cycloleucine [MeSH concept]
- cycloleucine [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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