" /> Cycloleucine - CISMeF





Preferred Label : Cycloleucine;

NCIt synonyms : 1-Aminocyclopentane; 1-aminocyclopentanecarboxylic acid; ACPC; ACP;

NCIt related terms : CB 1639;

NCIt definition : A non-metabolizable synthetic amino acid, formed through the cyclization of the amino acid leucine, with immunosuppressive, antineoplastic, and cytostatic activities. Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production; RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted. This agent is also a competitive inhibitor at the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor.;

UNII : 0TQU7668EI;

InChIKey : NILQLFBWTXNUOE-UHFFFAOYSA-N;

CAS number : 52-52-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 52-52-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CB-1639;

Chemical formula : C6H11NO2;

NSC code : 1026;

Codes from synonyms : NSC0001026;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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