Breast Carcinoma with Osteoclast-Like Stromal Giant Cells

Preferred Label : Breast Carcinoma with Osteoclast-Like Stromal Giant Cells;

NCIt synonyms : Breast Carcinoma with Osteoclastic Giant Cells;

NCIt definition : An invasive breast adenocarcinoma characterised by the presence of non-neoplastic stromal osteoclastic giant cells. The carcinomatous component is usually an invasive ductal carcinoma, although all other breast adenocarcinoma subtypes have also been described. The prognosis depends on the characteristics of the adenocarcinomatous component, and is not related to the presence of the giant cells.;

Neoplastic status : Malignant;

Details

Origin ID

C40349;

UMLS CUI

C1511304;

Disease excludes abnormal cell
- Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
Disease may have findings
- Breast Lump [NCIt concept]
- Calcification [NCIt concept]
- Pain [NCIt concept]
Has associated anatomic sites
- Breast [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_excludes_molecular_abnormality
- Inactivating CDH1 Gene Mutation [NCIt concept]
- Loss of CDH1 Protein Expression [NCIt concept]
disease_has_abnormal_cell
- Adenocarcinoma Cell [NCIt concept]
- Ductal Carcinoma Cell [NCIt concept]
- Large Osteoclastic Giant Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Invasive Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Not Otherwise Specified Lesion [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Terminal Ductal Lobular Unit Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Mammary Epithelium [NCIt concept]
- Terminal Ductal Lobular Unit [NCIt concept]
disease_has_primary_anatomic_site
- Breast [NCIt concept]
disease_mapped_to_gene
- CCND1 Gene [NCIt concept]
- ERBB2 Gene [NCIt concept]
disease_may_have_molecular_abnormality
- CCND1 Gene Amplification [NCIt concept]
- CCND1 Protein Overexpression [NCIt concept]
- CCND1 mRNA Overexpression [NCIt concept]
- ERBB2 Gene Amplification [NCIt concept]
- ERBB2 Protein Overexpression [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]

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