Preferred Label : Ancitabine Hydrochloride;
NCIt synonyms : 6H-furo(2',3':4,5)oxazolo(3,2-a)pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,(2R(2alpha,3beta,3a
beta,9a beta)); Ancytabine Hydrochloride; Cyclocytidine HCL;
NCIt related terms : Cyclocytidine; Cyclocytidine hydrochloride; CycloCMP hydrochloride;
NCIt definition : The hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity.
Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently,
cytarabine is converted to the triphosphate form within the cell and then competes
with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders
the rotation of the molecule within DNA, DNA replication ceases, specifically during
the S phase of the cell cycle. Cytarabine agent also inhibits DNA polymerase, resulting
in a decrease in DNA replication and repair. Compared to cytarabine, a more prolonged,
consistent cytarabine-mediated therapeutic effect may be achieved with ancitabine
because of the slow hydrolytic conversion of ancitabine to cytarabine.;
UNII : 3T6920M469;
InChIKey : KZOWNALBTMILAP-JBMRGDGGSA-N;
CAS number : 10212-25-6;
Drug name : Ancid;
Molecule name : U-33, 624A;
Chemical formula : C9H11N3O4.ClH;
NSC code : 145668;
Codes from synonyms : NSC0145668;
Origin ID : C403;
UMLS CUI : C0877817;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
