Crotoxin - CISMeF

Preferred Label : Crotoxin;

NCIt synonyms : Ctrx; CTX;

NCIt definition : A toxic protein complex isolated from Crotalus durissus terrificus (South American rattlesnake) venom that is comprised of a basic neurotoxic subunit with phospholipase A2 (PLA2) activity and an acidic non-enzymatic, non-toxic subunit called crotapotin, with anticoagulant and immunomodulatory activities. The PLA2 subunit of crotoxin hydrolyzes the acyl groups in phosphoglycerides, acts as an anticoagulant by inhibiting the prothrombinase activity of coagulation factor Xa (F10a) and increases chloride-dependent current modulated by the cystic fibrosis transmembrane conductance regulator (CFTR). The PLA2 subunit may also metabolize eicosanoids, forming products that cause sequestration of lymphocytes in the lymph nodes and inhibit the spreading and phagocytic activity of macrophages. Crotoxin down-modulates the immune system, leading to the inhibition of both humoral and cellular immune responses.;

CAS number : 9007-40-3;

Details

Origin ID

C400;

UMLS CUI

C0010377;

Automatic exact mappings (from CISMeF team)
- Cerebrotendinous xanthomatosis [OMIM Phenotype]
- Cerebrotendinous xanthomatosis [ORDO Disease]
- Cerebrotendinous xanthomatosis [ICD-11 More detail]
- Cyclophosphamide (substance) [SNOMED CT concept]
- crotoxin A [MeSH concept]
- cytochrome P450 family 27 subfamily A member 1 [ORDO Gene]
Currated CISMeF NLP mapping
- crotoxin [MeSH Descriptor]
- crotoxin [MeSH concept]
False automatic mappings
- Cyclophosphamide [LOINC component]
- Product containing cyclophosphamide (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Hazardous or Poisonous Substance [UMLS semantic type]
UMLS correspondences (same concept)
- crotoxin [MeSH concept]
- crotoxin [MeSH Descriptor]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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