Preferred Label : Dideaza-5,6,7,8-Tetrahydrofolic Acid;
NCIt synonyms : Dideaza-5 6 7 8-Tetrahydrofolic Acid; DDATHF;
NCIt definition : An antimetabolite and folate analogue with anti-proliferative activity. Dideazatetrahydrofolic
acid inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the
first folate-dependent enzyme of the de novo purine synthesis pathway essential for
cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required
for DNA replication and RNA transcription. As a result, this agent causes cell cycle
arrest in S-phase, and ultimately inhibits tumor cell proliferation.;
CAS number : 95693-76-8;
Origin ID : C39894;
UMLS CUI : C1511896;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
