Insulin Receptor-Related Receptor

Preferred Label : Insulin Receptor-Related Receptor;

NCIt synonyms : Insulin Receptor-Related Protein; IR-Related Receptor; INSRR; IRR; EC 2.7.10.1;

NCIt definition : Insulin receptor-related protein (1297 aa, 144 kDa) is encoded by the human INSRR gene. This protein plays a role in pH-mediated signaling;

NCIt note : Insulin receptor-related protein is cleaved to form an alpha and a beta subunit. The mature receptor is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains form the ligand-binding domain, while the beta chains exhibit kinase activity. (UniProt);

Details

Origin ID

C39672;

UMLS CUI

C4082285;

Currated CISMeF NLP mapping
- insulin receptor-related receptor [MeSH concept]
- insulin receptor-related receptor [MeSH Supplementary Concept]
OMIM relation
- Insulin receptor-related receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- INSRR Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Cell Surface Receptor [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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