NCIt synonyms : Leukoplakia of the Esophagus; Esophagus Leukoplakia; Leukoplakia of Esophagus; Esophageal Epidermoid Metaplasia;
NCIt definition : A rare condition that usually affects the middle-to-distal esophagus in middle-aged
and elderly people. There is usually a history of tobacco smoking or alcohol intake.
Dysphagia is the presenting symptom. Morphologically, the lesions are well-demarcated
and are characterized by epithelial hyperplasia, thickened basal layer, prominent
granular cell layer, and hyperorthokeratosis. In a minority of patients this condition
is associated with adjacent high-grade squamous dysplasia and/or squamous cell carcinoma.;