Preferred Label : Tubby Signaling Pathway;
NCIt related terms : G-Protein Signaling Through Tubby Proteins;
Alternative definition : BIOCARTA: The tubby gene product is expressed in the brain and has been implicated
by mouse genetics in obesity and other disorders such as blindness. Structural analysis
predicts that this gene acts as a transcription factor, binding to DNA to regulate
gene expression. More recently, it was reported that tubby binds to phosphoinositides
in the plasma membrane, helping to localize this factor in the membrane region in
the absence of pathway activation. Tubby also interacts with Gq-alpha g-protein subunits,
localizing tubby to regions of g-protein activation. Activation of phosphatase C activity
and hydrolysis of membrane phosphoinositides leads to release of tubby from the plasma
membrane, allowing tubby to enter the nucleus to bind DNA and regulate transcription.
Some G-protein coupled receptors such as 5-HT2c may signal in part through tubby in
addition to calcium-mediated pathways and protein-kinase signaling pathways. The identity
of genes regulated by tubby and the mechanism by which tubby affects obesity remain
to be explored. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_tubbyPathway;
Origin ID : C39261;
UMLS CUI : C1519661;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
