Ran Cycling Pathway

Preferred Label : Ran Cycling Pathway;

NCIt related terms : Cycling of Ran in nucleocytoplasmic transport;

Alternative definition : BIOCARTA: Ran is a member of the Ras family of small GTPases. Ran is an important component of many crucial nucleocytoplasmic transport pathways. The cycling of Ran is controlled by the RanGTP-RanGDP gradient established by the Ran Guanine nucleotide exchange Factor (RanGEF) RCC1 and the Ran GTPase-activating Protein (RanGAP). These two proteins combine to create a Ran gradient where RanGDP is predominantly cytoplasmic. RCC1 binds to chromatin and so RanGTP is found associated with DNA. RCC1 dissociated GDP from Ran and allows GTP to be bound. As Ran leaves the nucleus the two Ran binding proteins, RanBP1 and RanBP2 cooperate with RanGAP to induce GTP hydrolysis of Ran. There are several nuclear import factors that use the Ran gradient as part of their translocation mechanism. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_ranPathway;

Details

Origin ID

C39214;

UMLS CUI

C1514718;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- E3 SUMO-Protein Ligase RanBP2 [NCIt concept]
- GTP-Binding Nuclear Protein Ran [NCIt concept]
- Ran GTPase-Activating Protein 1 [NCIt concept]
pathway_has_gene_element
- RAN wt Allele [NCIt concept]
- RANBP2 wt Allele [NCIt concept]
- RANGAP1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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