Preferred Label : Signal Dependent Regulation of Myogenesis Pathway;
NCIt related terms : Signal Dependent Regulation of Myogenesis by Corepressor MITR;
Alternative definition : BIOCARTA: The differentiation of muscle cells is regulated by many factors, including
the MyoD/MEF2 family of transcription factors. The MyoD/MEF2 dimer binds to promoters
to activate genes involved in muscle cell differentiation. One of the factors that
regulates the role of MyoD/MEF2 in myogenesis is the protein MEF2-interacting transcription
repressor (MITR), a transcriptional repressor. When MITR is bound to MEF2, myogenesis
genes are repressed rather than being activated. The transcriptional repression by
MITR occurs in part at least through interaction with the CtBP (carboxy-terminal binding
protein) corepressor. The inhibitory activity of MITR is itself regulated by the calmodulin
dependent protein kinase CAMK. When CAMK is activated by factors such as IGF-1, it
phosphorylates two specific residues in MITR, ser218 and ser448. Phosphorylated MITR
does not bind to MEF2, but does bind to the protein 14-3-3, helping to block the repression
of myogenesis. CAMK also plays a role in myogenesis through phosphorylation of histone
deacetylase (HDAC), in which HDAC alters chromatin to repress myogenesis. Like MITR,
phosphorylation of HDAC removes the repression, allowing myogenesis to continue. MITR
shares sequence homology with HDAC, but itself lacks the enzyme motif. (This definition
may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_MITRPathway;
Origin ID : C39155;
UMLS CUI : C1519307;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
