Preferred Label : Polyadenylation Pathway;
NCIt related terms : Polyadenylation of mRNA;
Alternative definition : BIOCARTA: Gene expression requires the coordination and integration of multiple processes,
including transcription, splicing, polyadenylation, nucleocytoplasmic export, and
translation of mRNAs. Posttranscriptional addition of poly (A) to the 3' end of mRNA
is an important process conserved from bacteria to humans. In eukaryotes, polyadenylation
is essential for the stability of many mRNAs and also influences the efficiency of
translation. Most histone-mRNAs and all snRNAs (except U6), however are not polyadenylated.
The mature mRNA moves to the nuclear surface and is exported through nuclear pores.
(This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_cpsfPathway;
Origin ID : C39034;
UMLS CUI : C1158727;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- has_gene_product_element
- pathway_has_gene_element
