Preferred Label : ADP-Ribosylation Pathway;
NCIt related terms : ADP-Ribosylation Factor;
Alternative definition : BIOCARTA: ADP-ribosylation factors (ARFs) are 20-kDa guanine nucleotide-binding proteins,
members of the Ras GTPase superfamily that were initially recognized and purified
because of their ability to stimulate the ADP-ribosyltransferase activity of the cholera
toxin A subunit. We now know that they are critical components of several different
vesicular trafficking pathways in all eukaryotic cells and activators of specific
phospholipase Ds (PLDs). ARF interacts with many proteins and other molecules that
regulate its state of activation or are involved in its intracellular function. Arf
proteins cycle between GDP-bound, inactive and GTP-bound, active forms, and the cycling
is regulated by specific GEPs and GAPs. Members of the Arf GEP family can be grouped
into two major subfamilies on the basis of their sequence similarities and functional
differences. The high-molecular-weight Arf GEP subfamily includes yeast Sec7, Gea1,
and Gea2, and mammalian BIG1/p200, BIG2, and GBF1, which all consist of 1,400-2,000
amino acid residues. Many Arf GAPs are multidomain proteins and have been found to
interact with multiple signaling molecules. For instance, ASAP1 has a PH domain, ankyrin
(ANK) repeats, proline-rich and Src-homology (SH) 3 domains and has been shown to
bind PI, P2, Src, and Crk. PAPa/PAG3, with a similar domain structure, binds phosphoinositides,
Src, Pyk, and paxillin. The GITs bind bARK, paxillin and the Rac/Cdc42 exchange factor
PIX (also known as Cool). ASAP-related proteins, ARAP1, 2 and 3 have Arf GAP, Rho
GAP, Ankyrin repeat, Ras-associating (RA), and five PH domains, and therefore have
the potential of integrating four signaling pathways. (This definition may be outdated
- see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_arapPathway;
Origin ID : C38989;
UMLS CUI : C1527266;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
