Preferred Label : O-Glycan Biosynthesis Pathway;
NCIt synonyms : O-Glycans Biosynthesis Pathway;
NCIt related terms : Mucin Type O-Glycan Biosynthesis; O-Glycan Biosynthesis;
Alternative definition : KEGG: O-glycans are a class of glycans that modify serine or threonine residues of
proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine
(GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including
galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose,
or xylose. Depending on the sugars added, there are four common O-glycan core structures,
cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated
glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids.
Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic.
Important modifications of mucin O-glycans include O-acetylation of sialic acid and
O-sulfation of galactose and N-acetylglucosamine.;
KEGG ID : hsa00512;
Origin ID : C38841;
UMLS CUI : C1518516;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
