Pancreatic Proteolytic Enzymes

Preferred Label : Pancreatic Proteolytic Enzymes;

NCIt synonyms : Pancreatic Enzymes, Proteolytic; Proteolytic Enzymes;

NCIt definition : Enzymes produced and secreted by the pancreas which aid in the proteolysis of proteins in the digestive tract. Pancreatic proteolytic enzymes include trypsin, chymotrypsin and carboxypeptidase; these enzymes are secreted as zymogens, inactive precursors of the enzymes, and are activated in the lumen of the digestive canal. Another proteolytic enzyme, enteropeptidase, is associated with the brush border of enterocytes; this enzyme catalyses the conversion of trypsinogen into trypsin which, in turn, can activate a number of other pancreatic zymogens. (NCI04);

Details

Origin ID

C38728;

UMLS CUI

C2825138;

Automatic exact mappings (from CISMeF team)
- Endopeptidase (substance) [SNOMED CT concept]
- Enzyme proteolytic [ICHI extension code]
- peptide hydrolases [MeSH Descriptor]
- proteolytic enzymes [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
Validated automatic mappings to NTBT
- Enzyme proteolytic [ICD-11 Extension code]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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