Preferred Label : Recombinant Colony Stimulating Factor;
NCIt synonyms : Recombinant Hematopoietic Colony-stimulating Factor; CSF; Therapeutic Colony Stimulating Factor;
NCIt definition : Glycoprotein growth factors produced by monocytes, macrophages, or activated lymphocytes
that stimulate the proliferation of bone marrow cells and differentiation of stem
cells into colonies of granulocytes, monocytes, or macrophages. These substances act
in either paracrine or autocrine fashion on marrow cells, appear to act synergistically
in complex and poorly understood ways. Each appears to exert actions on several lines
of progenitor cells and to influence end cell function. Treatment with colony-stimulating
factors (CSF) can help the blood-forming tissue recover from the effects of chemotherapy
and radiation therapy. These factors include interleukin-3 (IL-3), granulocyte colony-stimulating
factor (G-CSF), macrophage colony-stimulating factor (M-CSF), and granulocyte-macrophage
colony-stimulating factor (GM-CSF).;
Origin ID : C387;
UMLS CUI : C0376561;
Semantic type(s)
