Liposome-encapsulated OSI-7904

Preferred Label : Liposome-encapsulated OSI-7904;

NCIt related terms : OSI-7904L; OSI-7904;

NCIt definition : A liposome-encapsulated formulation of the benzoquinazoline folate analog OSI-7904 with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication. Liposome encapsulation improves the efficacy and increases the half-life of OSI-7904. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called thymidylate synthase inhibitors.;

UNII : ON177ZCE7M;

CAS number : 139987-54-5;

Molecule name : GS7904L; OSI-7904L;

Codes from synonyms : CDR0000377715;

Details

Origin ID

C38694;

UMLS CUI

C1328144;

Automatic exact mappings (from CISMeF team)
- ((S)-2-(5-(1,2-dihydro-3-methyl-1-oxobenzo(f)-quinazoline-9-yl)methyl)amino-1-oxo-2-isoindolynyl)-glutaric acid [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- OSI-7904L [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- OSI-7904L [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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