Preferred Label : Paricalcitol;
NCIt synonyms : Compound 49510; (7e,22e)-19-Nor-9,10-Secoergosta-5,7,22-Triene-1Alpha,3Beta,25-Triol;
NCIt definition : A synthetic noncalcemic, nonphosphatemic vitamin D analogue. Paricalcitol binds to
the vitamin D receptor and has been shown to reduce parathyroid hormone (PTH) levels.
This agent also increases the expression of PTEN ('Phosphatase and Tensin homolog
deleted on chromosome Ten'), a tumor-suppressor gene, in leukemic cells and cyclin-dependent
kinase inhibitors, resulting in tumor cell apoptosis and tumor cell differentiation
into normal phenotypes. (NCI04);
Alternative definition : NCI-GLOSS: A substance that is being used to treat overactive parathyroid glands in
patients with kidney failure. It is also being studied in the treatment of cancer.
Paricalcitol belongs to the family of drugs called vitamin D analogs.;
UNII : 6702D36OG5;
InChIKey : BPKAHTKRCLCHEA-UBFJEZKGSA-N;
CAS number : 131918-61-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 131918-61-1
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G-SRS /a ;
Drug name : Zemplar;
Chemical formula : C27H44O3;
ChEBI ID : CHEBI:7931;
Codes from synonyms : CDR0000340933;
Origin ID : C38693;
UMLS CUI : C0249582;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
