Preferred Label : Defined Green Tea Catechin Extract;
Obsolete resource : true;
NCIt synonyms : Polyphenon E;
NCIt definition : A proprietary formulation composed of a defined, decaffeinated green tea extract,
containing polyphenolic flavonol catechins, isolated from the plant Camellia sinensis
with antiviral, antioxidant, and potential chemopreventive activities. The primary
catechins found in green tea are epicatechin (EC), epigallocatechin (EGC), epicatechin-3
gallate (ECG), and epigallocatechin-3-gallate (EGCG), the most potent. As potential
chemopreventive agents, catechins scavenge free radicals; inhibit enzymes involved
in cell replication and DNA synthesis; interfere with cell-to-cell contact adhesion;
and inhibit various intracellular communication pathways required for cell division.
In addition, it has been postulated that EGCG may trap growth factors such platelet-derived
growth factor (PDGF) on cell membranes, immobilizing growth factors on cell membranes
and preventing ligand-receptor crosslinking and growth factor receptor activation.;
Alternative definition : NCI-GLOSS: A substance being studied in the prevention of cancer. It is made from
decaffeinated green tea, and contains chemicals called catechins, which are antioxidants.;
NCIt note : See 'Sinecatechins(C76005)';
Concept status : Retired_Concept;
Drug name : Polyphenon E;
Codes from synonyms : CDR0000350240;
Origin ID : C38689;
UMLS CUI : C1882421;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
