Preferred Label : Amsilarotene;
NCIt related terms : TAC-101;
NCIt definition : A retinobenzoic acid with potential antineoplastic activity. Amsilarotene inhibits
retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent
kinase (CDK) inhibitors, resulting in cell cycle arrest. This agent also causes a
cytotoxic decline in cyclin A and thymidylate synthase expression.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs
to the families of drugs called synthetic retinoids and angiogenesis inhibitors.;
UNII : Q1418F39MH;
InChIKey : VVTNSTLJOVCBDL-UHFFFAOYSA-N;
CAS number : 125973-56-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 125973-56-0
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G-SRS /a ;
Molecule name : TAC-101; TAC 101;
Chemical formula : C20H27NO3Si2;
Codes from synonyms : CDR0000367448;
Origin ID : C38684;
UMLS CUI : C2830076;
Automatic exact mappings (from CISMeF team)
- TAC 101 [MeSH Supplementary Concept]
- Semantic type(s)
- concept_is_in_subset
