Preferred Label : Nitric Oxide Synthase 2C;
Obsolete resource : true;
NCIt synonyms : NOS2C; Nitric Oxide Synthase IIC; NOSIIC; NOS Type IIC; Nitric Oxide Synthase-2C;
NCIt definition : Encoded by human NOS2C Gene (NOS Family), calcium/calmodulin stimulated homodimeric
Nitric Oxide Synthase 2C binds FAD and FMN cofactors, requires BH4 which may stabilize
the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine).
NO has antimicrobial and antitumoral activities in macrophages. NOS2C may bind SLC9A3R1.
IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation
by TYK2 in innate immunity. (NCI);
NCIt note : Wed Sep 26 15:24:34 EDT 2012 - Q14961 has been designated Obsolete and deleted by
UniProtKB/Swiss-Prot. The NOS2C gene is a pseudogene. No protein is encoded.;
Concept status : Retired_Concept;
Origin ID : C38569;
UMLS CUI : C1518335;
OMIM relation
- Semantic type(s)
