Progonadoliberin-1

Preferred Label : Progonadoliberin-1;

NCIt synonyms : Gonadotrophin Releasing Hormone-1; Progonadoliberin 1; Progonadoliberin I; GNRH1;

NCIt definition : Progonadoliberin-1 (92 aa, 10 kDa) is encoded by the human GNRH1 gene. This protein plays a role in regulating the secretion of both luteinizing and follicle-stimulating hormones (LH and FSH, respectively).;

NCIt note : Progonadoliberin-1 is cleaved into 2 active peptides comprised of either amino acid residues 24-33, which is called gonadoliberin-1 (gonadoliberin I; gonadorelin; gonadotropin-releasing hormone I; GnRH-I; luliberin I; luteinizing hormone-releasing hormone I; LH-RH I; prolactin release-inhibiting factor; PIF), or residues 37-92, which is called GnRH-associated peptide 1 (GnRH-associated peptide I). (UniProt);

Details

Origin ID

C38492;

UMLS CUI

C1521753;

OMIM relation
- Gonadotropin-releasing hormone 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
UMLS correspondences (same concept)
- GNRH1 protein, human [MeSH concept]
gene_encodes_gene_product
- GNRH1 Gene [NCIt concept]
- Peptide Hormone Gene [NCIt concept]
gene_product_expressed_in_tissue
- Hypothalamus [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Protein Secretion [NCIt concept]
- Reproduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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