" /> Transplacental Route of Administration - CISMeF





Preferred Label : Transplacental Route of Administration;

NCIt synonyms : Transplacental; T-PLACENT; Transplacental Route of Drug Administration;

NCIt definition : Administration of a drug to an embryo in utero via systemic administration of the substance to the pregnant mother. Drugs cross the placenta through passive diffusion, active transport, pinocytosis and filtration. The properties of drugs that determine placental transfer by passive diffusion include molecular weight, pKa, lipid solubility and protein binding. Drugs with molecular weight of over 500 D are transferred incompletely. Drug metabolism and uptake can be altered by placental enzymes.;

Alternative definition : CDISC: Administration through or across the placenta. (FDA); EDQM-HC: In utero exposure of an embryo/foetus to a medicinal product administered to the pregnant mother. Comment: This term is not intended to describe an authorised route of administration for use in marketing authorisations, and does not cover intentional administration of a medicinal product to an embryo/foetus. It is intended for use in adverse event reporting for pharmacovigilance purposes.;

FDA table : Route of Administration (C-DRG-00301);

Codes from synonyms : 415; 20083000;

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Keyword's position in hierarchy(ies) : arborescence

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02/06/2024


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