NCIt definition : Introduction of a drug directly into venous circulation over the time duration of
more than 30 minutes but less than 24 hours. Method results in 100% bioavailability
of the agent due to an absence of the absorption phase and provides a precise and
continuous mode of drug therapy, especially for drugs with a narrow therapeutic index.
To achieve the steady state quickly, the loading dose is used. Intravenously administered
drug is diluted in the pooled venous blood and pumped through lungs before entering
systematic circulation (lung first-pass effect). The target organ receives only the
fraction of drug corresponding to the fraction of received arterial blood.;
Alternative definition : NCI-GLOSS: A method of putting fluids, including drugs, into the bloodstream.;