Intrabiliary Route of Administration

Preferred Label : Intrabiliary Route of Administration;

NCIt synonyms : I-BILI; Intrabiliary Route of Drug Administration;

NCIt related terms : INTRABILIARY;

NCIt definition : Administration within the biliary system for selective delivery of the agent to targeted hepatobiliary tissues and cell types, the goal of which is utilization of optimal therapeutic dosages combined with a reduction in systemic toxicity. Strategies for improving the tissue specificity include the use of tissue-specific ligands and the focal administration of drugs. Focal delivery has been primarily directed at uptake by the hepatocyte basolateral membrane and has included direct intraparenchymal injection, portal venous infusion, hepatic arterial infusion, and surgical systems for temporarily isolating the liver from the vasculature.;

Alternative definition : CDISC: Administration within the bile, bile ducts or gallbladder. (FDA);

FDA table : Route of Administration (C-DRG-00301);

Codes from synonyms : 362;

Details

Origin ID

C38224;

UMLS CUI

C1512913;

Automatic exact mappings (from CISMeF team)
- Intrabiliary route (qualifier value) [SNOMED CT concept]
- intrabiliary [Radlex concept]
Semantic type(s)
- Functional Concept [UMLS semantic type]
concept_is_in_subset
- CDISC SDTM Route of Administration Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CDISC SEND Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
- FDA Structured Product Labeling Terminology [NCIt concept]
- SPL Drug Route of Administration Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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