Preferred Label : Epidural Route of Administration;
NCIt synonyms : EPIDUR; Epidural Route of Drug Administration;
NCIt related terms : Epidural use; Epidural;
NCIt definition : Administration of the drug in the epidural space, usually at the lumbar level of the
spine. The drug must initially cross the dura mater before exerting its effect on
the nervous system components. The drug is also subject to uptake into the rich epidural
plexus of veins. Uptake and distribution after epidural administration resembles that
seen after intramuscular injection. The portion of drug that is not taken into the
vascular compartment is available to cross the dura. Hydrophilicity is a major component
in the pharmacokinetics of drug transfer into the subdural space.;
Alternative definition : CDISC: Administration upon or over the dura mater. (FDA); EDQM-HC: Injection of a medicinal product into the epidural space.;
FDA table : Route of Administration (C-DRG-00301);