Preferred Label : Conjunctival Route of Administration;
NCIt synonyms : CONJUNC; Conjunctival Route of Drug Administration;
NCIt related terms : CONJUNCTIVAL;
NCIt definition : Administration of a drug to the conjunctiva, the most frequently used mode of ocular
drug delivery. Advantages of this topical route include direct, localized delivery
to the target tissue, good accessibility into the intraocular environment owing to
membrane permeability and large intercellular spaces, avoidance of hepatic first-pass
metabolism, convenience, and relative painlessness. Limitations include rapid drug
elimination due to lacrimation and nasolacrimal drainage, drug binding to, and metabolism
by, tear proteins, and target non-specificity as a result of systemic absorption through
the nasal mucosa and conjunctival vasculature.;
Alternative definition : CDISC: Administration to the conjunctiva, the delicate membrane that lines the eyelids
and covers the exposed surface of the eyeball. (FDA);
FDA table : Route of Administration (C-DRG-00301);
Codes from synonyms : 068;
Origin ID : C38194;
UMLS CUI : C1522483;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
