Polyamine Analog SL11093

Preferred Label : Polyamine Analog SL11093;

NCIt synonyms : 3,8,13,18-Tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane Tetrahydrochloride;

NCIt definition : A synthetic compound of the polyamine class of chemicals with potential antineoplastic activity. Natural endogenous polyamines bind to DNA and are involved in a number of cellular processes such as cell division, differentiation, and membrane function. SL11093 displaces these polyamines from their DNA binding sites, resulting in cessation of cell growth and cell death. (NCI04);

Molecule name : SL-11093; SL 11093; CGC 11093; CGC-11093;

NSC code : 724908;

Details

Origin ID

C38130;

UMLS CUI

C1259818;

Automatic exact mappings (from CISMeF team)
- 3,8,13,18-tetraaza-10,11-((E)-1,2-cyclopropyl)eicosane tetrahydrochloride [MeSH concept]
- 3,8,13,18-tetraaza-10,11-((E)-1,2-cyclopropyl)eicosane tetrahydrochloride [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- SL-11093 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SL-11093 [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- DNA Binding [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Cell Differentiation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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