Methionine Aminopeptidase 2 Inhibitor PPI-2458

Preferred Label : Methionine Aminopeptidase 2 Inhibitor PPI-2458;

NCIt synonyms : MetAP-2 Inhibitor PPI-2458;

NCIt related terms : PPI-2458;

NCIt definition : A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class. (NCI04);

UNII : NA0Y2SRR29;

CAS number : 431077-35-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 431077-35-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : PPI-2458;

NSC code : 720735;

Details

Origin ID

C38129;

UMLS CUI

C1505437;

Automatic exact mappings (from CISMeF team)
- PPI 2458 [MeSH concept]
- PPI 2458 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PPI 2458 [MeSH concept]
- PPI 2458 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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