Preferred Label : Murine Monoclonal Antibody 225;
NCIt synonyms : Anti-EGF Receptor IgG1(Hybritech);
NCIt definition : A mouse monoclonal antibody that was raised against human epidermal growth factor
(EGF) receptor. Antibody 225 competes with EGF or transforming growth factor-alpha
(TGF alpha) for receptor binding and thereby prevents ligand-induced receptor tyrosine
kinase activation resulting in the inhibition of proliferation of human cancer cells
that are stimulated by the TGFalpha/EGF receptor autocrine loop.;
NSC code : 632307;
Origin ID : C38116;
UMLS CUI : C1513758;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
