Preferred Label : Adenovirus-mediated Human Interleukin-12;
NCIt synonyms : Adenovirus-interleukin-12; Ad.hIL-12; Adenovirus Interleukin-12-Gene;
NCIt definition : A replication incompetent adenovirus encoding human pro-inflammatory cytokine interleukin-12
(IL-12) (Ad.hIL-12), with potential immunomodulating and antineoplastic activities.
Upon intratumoral administration, the adenovirus selectively infects and replicates
in tumor cells, which may result in tumor cell lysis. Synergistically, IL-12 expressed
by the adenovirus may activate the immune system by promoting the activation of natural
killer cells (NKs), inducing secretion of interferon-gamma and inducing cytotoxic
T cell responses against tumor cells, which may result in immune-mediated tumor cell
death and inhibition of tumor cell proliferation.;
Origin ID : C37515;
UMLS CUI : C1831638;
Semantic type(s)
- concept_is_in_subset
