Preferred Label : Hypericin;
NCIt synonyms : 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethyl-mesonapthtodianthron;
NCIt definition : An anthraquinone derivative that is naturally found in the yellow flower of Hypericum
perforatum (St. John's wort) with antidepressant, potential antiviral, antineoplastic
and immunostimulating activities. Hypericin appears to inhibit the neuronal uptake
of serotonin, norepinephrine, dopamine, gamma-amino butyric acid (GABA) and L-glutamate,
which may contribute to its antidepressant effect. Hypericin may also prevent the
replication of encapsulated viruses probably due to inhibition of the assembly and
shedding of virus particles in infected cells. This agent also exerts potent phototoxic
effects by triggering apoptotic signaling that results in formation of reactive oxygen
species.;
UNII : 7V2F1075HD;
InChIKey : BTXNYTINYBABQR-UHFFFAOYSA-N;
CAS number : 548-04-9;
Chemical formula : C30H16O8;
NSC code : 622946; 407313;
ChEBI ID : CHEBI:5835;
Origin ID : C37456;
UMLS CUI : C0063220;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
