NCIt definition : A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity.
Following metabolic activation by phosphorylation and incorporation into DNA, zebularine
inhibits DNA methyltransferase through covalent complex formation between the enzyme
and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction
of demethylation including the removal of aberrant methylation of promoter regions
of genes critical for normal cellular functions.;
UNII : 7A9Y5SX0GY;
CAS number : 3690-10-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 3690-10-6
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