Zebularine - CISMeF

Preferred Label : Zebularine;

NCIt synonyms : Pyrimidin-2-one beta-Ribofuranoside; 1-beta-D-Ribofuranosyl-2(1H)-pyrimidinone; 2-Pyrimidone-1-beta-D-riboside; 4-Deoxyuridine;

NCIt definition : A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits DNA methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions.;

UNII : 7A9Y5SX0GY;

CAS number : 3690-10-6;

NSC code : 309132;

ChEBI ID : CHEBI:46938;

Codes from synonyms : 50566;

Details

Origin ID

C37455;

UMLS CUI

C0084253;

Currated CISMeF NLP mapping
- Zebularine (substance) [SNOMED CT concept]
- pyrimidin-2-one beta-ribofuranoside [MeSH concept]
- pyrimidin-2-one beta-ribofuranoside [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Zebularine (substance) [SNOMED CT concept]
- pyrimidin-2-one beta-ribofuranoside [MeSH Supplementary Concept]
- pyrimidin-2-one beta-ribofuranoside [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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