" /> Tesetaxel - CISMeF





Preferred Label : Tesetaxel;

NCIt related terms : DJ-927;

NCIt definition : A semi-synthetic, orally bioavailable taxane derivative with potential antineoplastic and antiangiogenic properties. Tesetaxel binds to and stabilizes tubulin, promoting microtubule assembly and thereby preventing microtubule depolymerization. This may lead to cell cycle arrest and an inhibition of cell proliferation. This agent may also inhibit pro-angiogenic factors such as vascular endothelial growth factor (VEGF). As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of taxane derivative.;

UNII : UG97LO5M8Y;

InChIKey : MODVSQKJJIBWPZ-VLLPJHQWSA-N;

CAS number : 333754-36-2;

Molecule name : DJ-927; DJ 927;

Chemical formula : C46H60FN3O13;

Codes from synonyms : CDR0000367408; 487;

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Keyword's position in hierarchy(ies) : arborescence

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09/05/2025


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